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Innovative Research Reagents for Inflammation & Immune Responses
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Latest Product Highlights ArchiveNew IL-21 InVivoKine™ for Immunotherapy Research
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News & Press ReleasesAbcalis and AdipoGen Life Sciences Partner on Distributing Animal-free Recombinant Monoclonal and Multiclonal Antibodies on the Life Science Research Market Exercise-induced Irisin Attenuates Amyloid-β Pathology A recent study in Neuron describes a mechanism by which irisin limits Aβ accumulation in the brain. Irisin binds to its receptor integrin αV/β5 on astrocytes which down-regulates ERK-STAT3 signaling and induces NEP secretion leading to Aβ clearance. These new findings offer new potential for the protein irisin as a therapeutic target for Alzheimer's Disease (AD) treatment and prevention. |
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